A randomized clinical trial of mindfulness meditation versus exercise in Parkinson’s disease during social unrest (2024)

Kwok, J. Y. Y., Choi, E. P. H., Wong, J. Y. H., Lok, K. Y. W., Ho, M. H., Fong, D. Y. T., Kwan, J. C. Y., Pang, S. Y. Y., & Auyeung, M. (2023). A randomized clinical trial of mindfulness meditation versus exercise in Parkinson’s disease during social unrest. npj Parkinson's Disease, 9(1), Article 7. https://doi.org/10.1038/s41531-023-00452-w

Kwok, Jojo Yan Yan ; Choi, Edmond Pui Hang ; Wong, Janet Yuen Ha et al. / A randomized clinical trial of mindfulness meditation versus exercise in Parkinson’s disease during social unrest. In: npj Parkinson's Disease. 2023 ; Vol. 9, No. 1.

@article{d0fefbfd995440afaf4f940dffa93108,

title = "A randomized clinical trial of mindfulness meditation versus exercise in Parkinson{\textquoteright}s disease during social unrest",

abstract = "Clinical practice guidelines support resilience training and exercise for patients with Parkinson{\textquoteright}s disease (PD). This assessor-blinded, randomized clinical trial aimed to compare the effects of a modified mindfulness meditation program versus stretching and resistance training exercise (SRTE) in patients with mild-to-moderate PD. A total of 126 potential participants were enrolled via convenience sampling, of which 68 eligible participants were randomized 1:1 to receive eight weekly 90-min sessions of mindfulness meditation or SRTE. Compared to the SRTE group, generalized estimating equation analyses revealed that the mindfulness group had significantly better improvement in outcomes, particularly for improving depressive symptoms (d, −1.66; 95% CI, −3.31 to −0.02) at week 8 and maintaining emotional non-reactivity at week 20 (d, 2.08; 95% CI, 0.59 to 3.56). Both groups demonstrated significant immediate, small-moderate effects on cognition (effect size [d] = 0.36–0.37, p = 0.006–0.011). Compared with the SRTE, mindfulness meditation appeared to be a feasible and promising strategy for managing depressive symptoms and maintaining emotional stability, with comparable benefits on cognitive performance. To combat the psychospiritual and cognitive sequelae of social unrest and COVID-19 pandemic, the integration of mindfulness training into motor-oriented PD rehabilitation protocols is recommended to strengthen the resilience and minimize the psycho-cognitive comorbidities among patients with mild-to-moderate PD. Trial Registration: HKU Clinical Trials Registry identifier: HKUCTR-2681.",

author = "Kwok, {Jojo Yan Yan} and Choi, {Edmond Pui Hang} and Wong, {Janet Yuen Ha} and Lok, {Kris Yuet Wan} and Ho, {Mu Hsing} and Fong, {Daniel Yee Tak} and Kwan, {Jackie Cheuk Yin} and Pang, {Shirley Yin Yu} and Man Auyeung",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = dec,

doi = "10.1038/s41531-023-00452-w",

language = "English",

volume = "9",

number = "1",

}

Kwok, JYY, Choi, EPH, Wong, JYH, Lok, KYW, Ho, MH, Fong, DYT, Kwan, JCY, Pang, SYY & Auyeung, M 2023, 'A randomized clinical trial of mindfulness meditation versus exercise in Parkinson’s disease during social unrest', npj Parkinson's Disease, vol. 9, no. 1, 7. https://doi.org/10.1038/s41531-023-00452-w

A randomized clinical trial of mindfulness meditation versus exercise in Parkinson’s disease during social unrest. / Kwok, Jojo Yan Yan; Choi, Edmond Pui Hang; Wong, Janet Yuen Ha et al.
In: npj Parkinson's Disease, Vol. 9, No. 1, 7, 12.2023.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A randomized clinical trial of mindfulness meditation versus exercise in Parkinson’s disease during social unrest

AU - Kwok, Jojo Yan Yan

AU - Choi, Edmond Pui Hang

AU - Wong, Janet Yuen Ha

AU - Lok, Kris Yuet Wan

AU - Ho, Mu Hsing

AU - Fong, Daniel Yee Tak

AU - Kwan, Jackie Cheuk Yin

AU - Pang, Shirley Yin Yu

AU - Auyeung, Man

N1 - Publisher Copyright:© 2023, The Author(s).

PY - 2023/12

Y1 - 2023/12

N2 - Clinical practice guidelines support resilience training and exercise for patients with Parkinson’s disease (PD). This assessor-blinded, randomized clinical trial aimed to compare the effects of a modified mindfulness meditation program versus stretching and resistance training exercise (SRTE) in patients with mild-to-moderate PD. A total of 126 potential participants were enrolled via convenience sampling, of which 68 eligible participants were randomized 1:1 to receive eight weekly 90-min sessions of mindfulness meditation or SRTE. Compared to the SRTE group, generalized estimating equation analyses revealed that the mindfulness group had significantly better improvement in outcomes, particularly for improving depressive symptoms (d, −1.66; 95% CI, −3.31 to −0.02) at week 8 and maintaining emotional non-reactivity at week 20 (d, 2.08; 95% CI, 0.59 to 3.56). Both groups demonstrated significant immediate, small-moderate effects on cognition (effect size [d] = 0.36–0.37, p = 0.006–0.011). Compared with the SRTE, mindfulness meditation appeared to be a feasible and promising strategy for managing depressive symptoms and maintaining emotional stability, with comparable benefits on cognitive performance. To combat the psychospiritual and cognitive sequelae of social unrest and COVID-19 pandemic, the integration of mindfulness training into motor-oriented PD rehabilitation protocols is recommended to strengthen the resilience and minimize the psycho-cognitive comorbidities among patients with mild-to-moderate PD. Trial Registration: HKU Clinical Trials Registry identifier: HKUCTR-2681.

AB - Clinical practice guidelines support resilience training and exercise for patients with Parkinson’s disease (PD). This assessor-blinded, randomized clinical trial aimed to compare the effects of a modified mindfulness meditation program versus stretching and resistance training exercise (SRTE) in patients with mild-to-moderate PD. A total of 126 potential participants were enrolled via convenience sampling, of which 68 eligible participants were randomized 1:1 to receive eight weekly 90-min sessions of mindfulness meditation or SRTE. Compared to the SRTE group, generalized estimating equation analyses revealed that the mindfulness group had significantly better improvement in outcomes, particularly for improving depressive symptoms (d, −1.66; 95% CI, −3.31 to −0.02) at week 8 and maintaining emotional non-reactivity at week 20 (d, 2.08; 95% CI, 0.59 to 3.56). Both groups demonstrated significant immediate, small-moderate effects on cognition (effect size [d] = 0.36–0.37, p = 0.006–0.011). Compared with the SRTE, mindfulness meditation appeared to be a feasible and promising strategy for managing depressive symptoms and maintaining emotional stability, with comparable benefits on cognitive performance. To combat the psychospiritual and cognitive sequelae of social unrest and COVID-19 pandemic, the integration of mindfulness training into motor-oriented PD rehabilitation protocols is recommended to strengthen the resilience and minimize the psycho-cognitive comorbidities among patients with mild-to-moderate PD. Trial Registration: HKU Clinical Trials Registry identifier: HKUCTR-2681.

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U2 - 10.1038/s41531-023-00452-w

DO - 10.1038/s41531-023-00452-w

M3 - Article

AN - SCOPUS:85146791758

VL - 9

JO - npj Parkinson's Disease

JF - npj Parkinson's Disease

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ER -

Kwok JYY, Choi EPH, Wong JYH, Lok KYW, Ho MH, Fong DYT et al. A randomized clinical trial of mindfulness meditation versus exercise in Parkinson’s disease during social unrest. npj Parkinson's Disease. 2023 Dec;9(1):7. doi: 10.1038/s41531-023-00452-w